Modular phage vector platform for sonodynamic therapy
AssigneeAlma Mater Studiorum - Università di Bologna
InventorsAlberto Danielli, Matteo Calvaresi, Matteo Di Giosia, Andrea Cantelli, Francesco Starinieri, Michela Nigro, Edoardo Sarti
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Abstract
The present invention relates to a phage or a composition that comprises it, wherein said phage expresses at least one specific recognition element and is furthermore conjugated with at least 300 molecules of a sonosensitiser. The invention further relates to the use of said phage in a sonodynamic therapy.
Claims16
A method for treating a tumour or an infection, said method comprising administering to a subject a phage expressing at least one specific recognition element, said specific recognition element being conjugated with at least 300 molecules of a sonosensitiser or a composition comprising the phage and excipients and/or additional substances and/or pharmaceutically accepted carriers wherein the infection is selected from a bacterial, viral or fungal infection, and wherein the phage is administered in association or in combination with ultrasound.
Dependencies are inferred from the claim text.