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US 12,622,958 B2Granted
Virus-like particles containing RSV antigen protein and vaccines using the same
AssigneeUniversity-Industry Cooperation Group of Kyung Hee University
InventorsFu-Shi Quan, Ki-Back Chu, Su-Hwa Lee
Life of this patent
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Abstract
An RSV virus-like particle which includes a chimeric protein that includes a core consisting of an influenza M1 protein, an RSV-derived preF protein, an RSV-derived G protein or part of G protein displayed on the surface of the core, can exhibit excellent effects in terms of inhibiting RSV virus infection and inhibiting the inflammatory response of the lungs.
Claims6
A respiratory syncytial virus (RSV)-like particle comprising:
- a core consisting of an influenza virus matrix protein 1 (M1);
- and
- an antigenic protein displayed on the surface of the core,
- wherein the antigen protein comprises a preF protein derived from RSV consisting of an amino acid sequence of SEQ ID NO:
- 12, and a chimeric protein, which comprises a first tandem sequence consisting of an amino acid sequence of SEQ ID NO:
- 9 and a second tandem sequence consisting of an amino acid sequence of SEQ ID NO:
- 10.
4 more elements
Dependencies are inferred from the claim text.