Consensus sequence of the antigen telomerase and the use thereof in preventive and therapeutic vaccination
AssigneeEvviVax S.r.l.
InventorsLuigi Aurisicchio, Antonella Conforti
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Abstract
A consensus sequence of the antigen telomerase (ConTRt) can be generated and used in preventive and therapeutic vaccination. The consensus sequence of telomerase was generated by the fusion of two sequences, one belonging to human telomerase (hTERT) and the other to dog telomerase (dTERT), with the aim of developing an effective vaccine for the treatment of tumors expressing both human and dog telomerase, hence in both the human and veterinary sectors.
Claims11
A nucleotide sequence encoding an amino acid consensus sequence of the antigen telomerase comprising sequence SEQ ID NO:1, wherein the nucleotide sequence comprises the nucleotide sequence SEQ ID NO:
- 4, or a sequence having a sequence identity of at least 80% with respect to SEQ ID NO:4, and a nucleotide sequence encoding the profilin-like protein of Toxoplasma Gondii, wherein the nucleotide sequence encoding the profilin-like protein of Toxoplasma Gondii comprises SEQ ID NO:
- 31.
Dependencies are inferred from the claim text.