GLP-1/GIP dual agonists

A polypeptide comprising the amino acid sequence:

• (SEQ ID NO:
• 3)
• Y-X1-E-G-T-F-T-S-D-Y-S-I-X2-L-D-K-I-A-Q-X3-A-F-V-
• Q-W-L-X4-A-G-G-P-S-S-G-A-P-P-P-S,
• or a pharmaceutically acceptable salt thereof,
• wherein:
• X1 is Aib or (L)-norvaline;
• X2 is Leu or (L)-norvaline;
• X3 is Lys, wherein the side chain amino (ε-amino) group of the Lys is acylated with a moiety having the formula:
• wherein:
• U is —C(O)—CH2—O—(CH2)2—O—(CH2)2—NH—}, wherein} is point of attachment to W;
• W is —C(O)—C(CH3)2—NH—], wherein] is point of attachment to Y;
• Y is —C(O)—(CH2)2—CH(COOH)NH—, wherein — is point of attachment to Z;
• and
• Z is —C(O)—(CH2)n—COOH or —C(O)—(CH2)n—CH3, wherein n is an integer from 14 to 20;
• X4 is Ile;
• and
• the acid group of the C-terminal amino acid is a free carboxylic acid group or is amidated as a C-terminal primary amide.