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US 12,622,925 B2Granted
Edible enterosorbents used to mitigate acute exposures to ingestible environmental toxins following outbreaks, natural disasters and emergencies
OwnerTimothy D Phillips, Meichen Wanginventors
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Abstract
An edible enterosorbent containing a treated enterosorbent, wherein the treated enterosorbent comprises a parent sorbent that has been acid and/or lecithin treated, and wherein the treated sorbent is operable for adsorption of one or more toxins from a gastrointestinal tract of a living being when introduced thereto, such that a bioavailability of and exposure of the living being to the one or more toxins is decreased. Methods of making and utilizing the edible enterosorbent are also provided.
Claims4
A method for reducing exposure to acute ingestible toxins in a living being, comprising:
- (a) administering an edible enterosorbent composition to the gastrointestinal tract of the living being at risk of acute toxin exposure, wherein the composition comprises:
- (i) an acid-treated montmorillonite mineral selected from montmorillonite clay, sodium montmorillonite clay, or calcium montmorillonite clay, wherein the mineral is pre-treated with a strong acid to enhance toxin-binding sites, has a particle size less than 80 microns, and is free from detectable levels of total tetra-dioxin above 0.024 pg/L, total penta-dioxin above 0.025 pg/L, and total hexa-dioxin above 0.039 pg/L;
- and
- (ii) lecithin in an amount of >2% to 75% by weight, capable of up to 100% cation exchange capacity;
- (b) selecting one or more acute ingestible toxins to be reduced from the group consisting of pentachlorophenol, benzo[a]pyrene, lindane, diazinon, aldicarb, linuron, industrial solvents, polycyclic aromatic hydrocarbons, 1,2,3-trichloropropane, phenol, benzene, toluene, pyrene, naphthalene, 2,4-D, 2,4-dinitrophenylhydrazine, atrazine, glyphosate, dichlorodiphenyltrichloroethane, paraquat, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, bisphenol A, bisphenol S, dibutyl phthalate, di-2-ethylhexyl phthalate, dieldrin, polychlorinated biphenyls (PCB 77, PCB 126, PCB 153, PCB 157, PCB 154, PCB 155), trifluralin, or combinations thereof;
- (c) waiting a period of time;
- and
- (d) repeating step (a) until exposure to the selected acute ingestible toxins is reduced;
- wherein the edible enterosorbent composition binds the selected acute ingestible toxins with a maximum binding capacity (Qmax) or distribution coefficient (Kd) greater than that of the montmorillonite mineral alone, as determined by reduced microbe colony forming units, improved hydra morphology scale (0 to 10, where 10 is normal and 0 is disintegrated), or both.
6 more elements
A method for reducing acute ingestible toxin exposure risk from an environment contaminated with toxins, comprising:
- (a) introducing an edible enterosorbent composition into a toxin contaminated environment, wherein the composition comprises:
- (i) an acid-treated montmorillonite mineral selected from montmorillonite clay, sodium montmorillonite clay, or calcium montmorillonite clay, wherein the mineral is pre-treated with a strong acid to enhance toxin-binding sites, has a particle size less than 80 microns, and is free from detectable levels of total tetra-dioxin above 0.024 pg/L, total penta-dioxin above 0.025 pg/L, and total hexa-dioxin above 0.039 pg/L;
- and
- (ii) lecithin in an amount of >2% to 75% by weight, configured to enhance cation exchange capacity;
- (b) selecting one or more acute ingestible toxins to be reduced from the group consisting of:
- pentachlorophenol (PCP);
- benzo[a]pyrene (BaP);
- lindane;
- diazinon;
- aldicarb;
- linuron;
- industrial solvents;
- polycyclic aromatic hydrocarbons (PAHs);
- 1,2,3-Trichloropropane (TCP);
- Phenol;
- Benzene;
- Toluene;
- Pyrene;
- BFF;
- Naphthalene;
- 2,4 D;
- 2,4-Dinitrophenylhydrazine (2,4-DNP);
- Atrazine;
- Glyphosate;
- Dichlorodiphenyltrichloroethane (DDT);
- Paraquat;
- α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA);
- Bisphenol A (BPA);
- Bisphenol S (BPS);
- Dibutyl phthalate (DBP);
- di-2-ethylhexyl phthalate (DEHP);
- Dieldrin;
- Polychlorinated biphenyls (PCBs);
- PCB 77;
- PCB 126;
- PCB 153;
- PCB 157;
- PCB 154;
- PCB 155;
- Trifluralin;
- or combinations thereof;
- or combinations thereof;
- (c) waiting a period of time;
- and
- (d) repeating step (a) until the acute ingestible toxin exposure risk in the environment is reduced;
- wherein the edible enterosorbent composition binds the selected acute ingestible toxins with a maximum binding capacity (Qmax) or distribution coefficient (Kd) greater than that of the montmorillonite mineral alone, as determined by reduced microbe colony forming units, a hydra morphology scale graded from 0 to 10 (where 10 is normal and 0 is disintegrated), or both.
43 more elements
Dependencies are inferred from the claim text.