Compositions and methods for metal containing formulations capable of modulating immune response
AssigneeThe Regents of the University of Michigan
InventorsJames J. Moon, Xiaoqi Sun
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Abstract
This disclosure provides compositions and methods for stimulating the innate immune response in a subject with agents capable of stimulating an innate immune response in a subject upon administration to the subject (e.g., damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs)). In particular, the present invention is directed to compositions of DAMPs/PAMPs and metals ions, as well as systems and methods utilizing such nanoparticles (e.g., in diagnostic and/or therapeutic settings).
Claims19
A composition comprising a nanoparticle comprising one or more stimulator of interferon genes (STING) agonists and/or Toll-Like receptor (TLR) agonists, and
- one or more cations selected from the group consisting of Zn2+, Mn2+, Fe2+, Fe3+, Cu2+, Ni2+, Co2+, Pb2+, Sn2+, Ru2+, Au2+, Mg2+, VO2+, Al3+, Co3+, Cr3+, Ga3+, Tl3+, Ln3+, MoO3+, Cu+, Au+, Tl+, Ag+, Hg2+, Pt2+, Pb2+, Hg2+, Cd2+, Pd2+, Pt4+, Na+, and K+,
- wherein the nanoparticle further comprises poly (histidine)-polyethylene glycol (PH-PEG) or lipid-poly-histidine.
Dependencies are inferred from the claim text.