High-activity Wnt pathway inhibitor compound

A compound having a structure represented by formula I or a pharmaceutically acceptable salt, an isotopic derivative, end a stereoisomer thereof for inhibiting Wnt pathway activity:

• wherein:
• means existence or non-existence;
• R1 represents C1-C6 alkyl, C3-C6 cycloalkyl, C6-C10 aryl, 5-10 membered heteroaryl, and said R1 can be optionally substituted by 0, 1, 2, 3 substituents selected from hydrogen, halogen, (C1-C6)alkyl, ORa, halogenated (C1-C6) alkyl, (C3-C6) cycloalkyl, halogenated (C3-C6) cycloalkyl, cyano, SRa, halogenated (C1-C6) alkoxy, halo (C3-C6) cycloalkoxy, halo (C1-C6) alkylthio, (C3-C6) cycloalkyloxy, (C3-C6) cycloalkylthio, halo (C3-C6) cycloalkylthio;
• X represents —(CRaRa′)m—, —(CRaRa′)m O(CRaRa′)n-, —(CRaRa′)m S(RaRa′)n;
• Cy represents C6-C10 aryl or 5-10 membered heteroaryl, and it can be optionally substituted by 0, 1, 2, 3 substituents selected from:
• hydrogen, halogen, —ORa, (C1-C6) alkyl, halo (C1-C6) alkyl, (C3-C6) cycloalkyl, cyano, hydroxyl (C1-C6) alkyl;
• R2 represents hydrogen, (C1-C6) alkyl, halo (C1-C6) alkyl, (C3-C6) cycloalkyl, hydroxyl (C1-C6) alkyl;
• R3 and R3′ independently represent hydrogen, halogen, ORa, (C1-C6) alkyl, (C3-C6) cycloalkyl, hydroxyl (C1-C6 alkyl), (C1-C6) alkoxy (C1-C6) alkyl;
• alternatively, R3 and R3′ form a 3-6 membered saturated or unsaturated ring together with the carbon atom connected to them, and the ring can also optionally contain 1 or 2 heteroatoms selected from O, S, and N;
• and the ring can also be optionally substituted by 0, 1, 2 halogens, hydroxyl, C1-C6 alkyl;
• alternatively, R2, R3 or R2′, R3 form a 4-6 membered saturated or unsaturated ring together with the atoms connected to them, the ring may optionally contain 1 or 2 heteroatoms selected from O, S, and N;
• and the ring can also be optionally substituted by 0, 1, 2 halogens, hydroxyl, C1-C6 alkyl;
• R4 and R4′ independently represent hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, hydroxyl (C1-C6 alkyl), halogenated (C1-C6 alkyl), (C1-C6) alkoxy (C1-C6) alkyl;
• alternatively, R4 and R4′ together form ═O;
• RT and RT′ each independently represent hydrogen, C1-C6 alkyl, halogenated (C1-C6 alkyl), hydroxyl C1-C6 alkyl, C3-C6 cycloalkyl, halogen, —ORa;
• alternatively, RT and RT′ together form a 3-6 membered ring with the atom connected to them;
• wherein, when represents absence, A represents (CRLRL′)p, wherein RL and RL′ each independently represent hydrogen, C1-C6 alkyl, halo (C1-C6 alkyl), hydroxyl (C1-C6 alkyl), C3-C6 cycloalkyl, halogen, ORa, or RL and RL′ together form a 3-6 membered ring with the carbon atom connected to them, and the ring can optionally contain 0, 1, 2 heteroatoms selected from O, S, N, and the ring can also be optionally substituted by 0, 1, 2 halogens, hydroxyl;
• wherein, when represents existence, A represents CRH, wherein RH means hydrogen, C1-C6 alkyl, halogenated (C1-C6 alkyl), hydroxyl (C1-C6 alkyl), C3-C6 cycloalkyl, halogen, ORa;
• wherein, Ra, Ra′ independently represent hydrogen and C1-C6 alkyl;
• wherein, m, n, and p each independently represent 0, 1, 2.