Folate salts for medical use
AssigneeAprofol AG
InventorsMartin Ulmann, Gerd Wiesler, Arthur Bodenmüller, Markus Müller
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Abstract
The invention relates to amorphous folate salt. The salt consists of a folate anion and an organic cation. The folate anion is selected from the group consisting of 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, (6S)-tetrahydrofolic acid, 5,10-Methylene-(6R)-tetrahydrofolic acid, and its oxidized derivatives JK12A and Mefox, and the cation is an organic compound selected from the group arginine, choline, acetylcholine, 1,1-dimethyl-biguanidin phenylethylbiguanidin, betaine-methylester and dimethylaminoethanol. The cation is an organic compound with a complementary pharmacological activity.
Claims5
An amorphous folate salt consisting of a tetrahydrofolic acid anion and an organic cation characterized in that the anion is selected from the group consisting of 10-formyl-(6R)-tetrahydrofolic acid, 5-methyl-(6S)-tetrahydrofolic acid, (6S)-tetrahydrofolic acid, 5, 10-Methylene-(6R)-tetrahydrofolic acid, and its oxidized derivatives JK12A and Mefox, and the cation is an organic compound selected from the group di-choline, di-acetylcholine, di-1,1-dimethyl-biguanidin, di-phenylethylbiguanidin, and di-betaine-methylester, wherein the folate salts have a high solubility in an apolar solvent, said apolar solvent having a relative polarity of 0.82 compared to water.
Dependencies are inferred from the claim text.