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US 12,622,891 B2Granted
AMP-activated protein kinase activator
AssigneeKyoto Pharmaceutical University
InventorsSusumu Nakata, Naoto Kojima
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Abstract
The present invention aims to provide a novel AMP-activated protein kinase activator. The present invention relates to a compound represented by the formula (I): wherein each symbol is as described in the specification, or a salt thereof, or a hydrate thereof. In addition, the present invention relates to an AMP-activated protein kinase activator containing the aforementioned compound, and a medicament containing the aforementioned compound for the prophylaxis and/or treatment of cancer.
Claims11
A compound represented by the formula (I):
- wherein
- R1 is a propyl group or a C8-10 alkyl group, each of which is optionally substituted by a hydroxy group or a C2-6 alkynyl group;
- R2 is a thienyl group or a pyrazolyl group, each of which is optionally substituted by a substituent selected from the group consisting of a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C6-10 aryl group, a cyano group, a nitro group, a carboxy group, a C1-6 alkoxy-carbonyl group, and an acyl group,
- L1 is a C1-20 alkylene group optionally substituted by a hydroxy group,
- L2 is a divalent group represented by the formula:
- *NHC(═O)**
- or the formula:
- *NHS(O)2**
- wherein * represents a bonding position to L1;
- and ** represents a bonding position to R2;
- and
- n is an integer of 1 to 8,
- or a pharmaceutically acceptable salt thereof, or a hydrate thereof.
10 more elements
Dependencies are inferred from the claim text.