Devices, systems, and methods for facilitating tissue delivery of drug
AssigneeGeorgia Tech Research Corporation
InventorsMohammed Saad Bhamla, Gaurav Byagathvalli, Dengning Xia, Mark R. Prausnitz
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Abstract
Devices and methods are provided for administering a drug to a biological tissue in a patient, such as by intracellular and/or dermal delivery. The device includes a piezoelectric pulse generator; and an array of microneedle electrodes electrically coupled to the piezoelectric pulse generator, wherein the device, following insertion of the microneedle electrodes into the biological tissue, is configured to generate and deliver one or more electrical pulses through the microneedle electrodes effective to electroporate cells in the biological tissue and enable delivery of a drug into the electroporated cells.
Claims30
A device for use in administering a drug into or across a biological tissue in a patient, comprising:
- a piezoelectric pulse generator;
- and
- an array of microneedle electrodes electrically coupled to the piezoelectric pulse generator,
- wherein the device, following insertion of the microneedle electrodes into the biological tissue, is configured to generate and deliver one or more electrical pulses through the microneedle electrodes effective to electroporate cells in the biological tissue and enable delivery of a drug into the electroporated cells, and
- wherein the piezoelectric pulse generator comprises:
- a piezoelectric crystal;
- a mechanism configured to strike a surface of the piezoelectric crystal effective to generate the one or more electrical pulses;
- and
- electrical connections configured to conduct the one or more electrical pulses to the microneedle electrodes.
Dependencies are inferred from the claim text.