Tissue based bioprosthetic heart valve
AssigneeBoston Scientific Corporation
InventorArnaud Humair
Life of this patent
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Abstract
Embodiments herein relate to bioprosthetic heart valves. In an embodiment, a heart valve replacement system is included having a delivery catheter can include a heart valve accommodation region; and a heart valve disposed around the delivery catheter at the heart valve accommodation region of the delivery catheter, the heart valve can include a frame; and a plurality of valve leaflets coupled to the frame; wherein the valve leaflets include an animal tissue, the animal tissue can include from 15% to 50% by weight water; and from 20% to 70% by weight glycerol; a package defining an interior volume, wherein the delivery catheter and the heart valve are disposed within the package. Other embodiments are also included herein.
Claims20
A method of making a heart valve replacement device comprising:
- cutting animal tissue into leaflets;
- coupling the leaflets to a frame to form a heart valve;
- contacting the leaflets with a composition comprising glycerol;
- removing moisture from the leaflets in an environment at above room temperature and/or below atmospheric pressure;
- and
- placing the heart valve on a delivery catheter;
- wherein coupling the leaflets to the frame occurs prior to removing moisture from the leaflets in the environment at above room temperature and/or below atmospheric pressure;
- wherein the leaflets of the heart valve are glutaraldehyde-free when placed on the delivery catheter.
Dependencies are inferred from the claim text.