Insect control nanobodies and uses thereof
AssigneeIBI-Ag Innovative Bio Insecticides Ltd.
InventorsRony Oren-Benaroya, Amir Ayali, Jessica Monserrate, Jeroen Van Rie
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Abstract
Insect control nanobodies are provided. Accordingly there is provided a nanobody which specifically binds to an insect polypeptide selected from the group consisting of: a polypeptide comprising a chitin binding domain (CBD), V-ATPase subunit c, trehalase, cytochrome p450 monooxygenase, chitin deacetylase, chitin synthase and NPC1 sterol transporter, wherein binding of the nanobody to the insect polypeptide confers an insect control activity to the nanobody. Also provided are polynucleotides encoding the nanobody, host cells expressing the nanobody and methods of using it.
Claims21
A VHH antibody which specifically binds to an insect chitin deacetylase comprising complementarity determining regions (CDRs) as set forth in SEQ ID NOs:
- 351, 347 and 356 arranged in a sequential order from N to C on said nanobody,
- wherein binding of said nanobody to said insect chitin deacetylase confers an insect control activity to said VHH antibody.
A composition comprising a VHH antibody which specifically binds to an insect chitin deacetylase comprising complementarity determining regions (CDRs) as set forth in SEQ ID NOs:
- 351, 347 and 356 arranged in a sequential order from N to C on said nanobody;
- and a toxin moiety having an insect control activity.
Dependencies are inferred from the claim text.