Diagnostics of mild or adversed periodontitis

A method of treating a human patient who has mild periodontitis or advanced periodontitis, comprising;

• detecting in a sample of saliva of the human patient the proteins:
• Pyruvate Kinase (PK) and Matrix metalloproteinase-9 (MMP9);
• determining a testing value reflecting joint concentrations determined for said proteins;
• and
• assessing the presence of mild periodontitis or advanced periodontitis in the patient on the basis of the concentrations of said proteins in said sample, comprising comparing said determined testing value with a threshold value reflecting in the same manner the joint concentrations associated with advanced periodontitis, so as to assess whether the testing value is indicative for mild periodontitis or for advanced periodontitis in said patient;
• and
• administering, to the human patient for which the assessment is indicative for mild periodontitis or for advanced periodontitis, an anti-microbial therapeutic agent to the gum tissue of the human patient.

A method of treating periodontitis comprising:

• detecting the proteins:
• Pyruvate Kinase (PK) and Matrix metalloproteinase-9 (MMP9) in a human patient, by:
• (a) obtaining a saliva sample from a human patient;
• and
• (b) detecting whether the proteins are present in the sample by contacting the sample with one or more detection reagents for binding said proteins and detecting binding between each protein and the one or more detection reagents;
• and
• administering, to the human patient for which the proteins are detected in concentrations indicative for mild periodontitis or for advanced periodontitis, an anti-microbial therapeutic agent to the gum tissue of the human patient.