Characterization of particles in solution

Method to measure characteristics of particles in solution, said method comprising the steps of:

• providing a vessel comprising a sample of said particles in solution;
• providing a monochromatic light source and a light detector;
• transmitting light from the monochromatic light source to the vessel comprising the sample;
• detecting light emitted from the vessel with the light detector;
• and
• determining characteristics of said particles in solution comprised in the sample based on a dynamic light scattering (DLS) measurement,
• wherein the DLS measurement comprises the steps of
• obtaining an analog output signal obtained from the light detector;
• and
• processing the obtained analog output signal,
• wherein the step of processing the obtained analog output signal comprises the step of digitalizing the obtained analog output signal into a digitalized output signal, wherein the digitalized output signal is further processed with the step(s) of
• i) processing the digitalized output signal as a digitalized single photon pulse signal, in case an intensity of the light detected by the light detector is below a predetermined number of detected photons per second;
• and/or
• ii) processing the digitalized output signal as discrete values of an analog signal, in case the intensity of the light detected by the light detector is above said predetermined number of detected photons per second.