Methods of diagnosing malignant diseases
AssigneeSt Innovative Diagnostics Ltd
InventorEsther Rabizadeh
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Abstract
A method for diagnosing a malignant proliferative disease or disorder in a subject, and/or for following up, monitoring or prognosticating the therapy of a malignant proliferative disease or disorder in a subject is disclosed. The method is based on measurement of platelet-mediated fibrinogen-like protein 2 (FGL2) activity in a sample essentially comprising platelets obtained from the subject. In accordance with the disclosed method, platelet-mediated FGL2 activity level higher than control is indicative of the presence of a malignant proliferative disease or disorder in a subject.
Claims16
A kit for diagnosis, follow-up or prognosis of a malignant proliferative disease or disorder, the kit comprising:
- (a) means for measuring platelet-mediated FGL2 activity level in a biological sample containing platelets of a subject to be tested;
- said means comprising (1) factor X deficient plasma;
- (2) tissue factor or an artificial tissue factor surrogate;
- (3) FGL2 activity level predetermined calibration curve;
- (b) instructions for measuring platelet-mediated FGL2 activity level in said sample comprising measuring coagulation time of said sample being suspended in said factor X deficient plasma and transforming coagulation time into FGL2 activity level using said predetermined calibration curve;
- and, optionally, (c) at least one means for collecting a biological sample containing platelets of a subject to be tested;
- and/or (d) at least one control sample.
Dependencies are inferred from the claim text.