Antibody for detecting acetylation of COX2 protein, and uses thereof
AssigneeKyungpook National University Industry-Academic Cooperation Foundation
InventorsJae-Sung Bae, Hee Kyung Jin, Ju Youn Lee
Life of this patent
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Abstract
The present invention relates to an antibody for detecting acetylation of COX2 protein, and uses thereof, and more specifically, to an antibody that specifically recognizes the acetylation of S565 residue of the COX2 protein; and uses thereof for diagnosing neurodegenerative diseases or inflammatory diseases. An antibody or a functional fragment thereof according to the present invention specifically binds to an acetylated residue of COX2 protein, and can thus be very effectively used for diagnosing neurodegenerative diseases, inflammatory diseases, and the like in which the degree of acetylation of S565 residue of the COX2 protein is reduced.
Claims17
An antibody or a functional fragment thereof that specifically recognizes the acetylation of cyclooxygenase 2 (COX2) protein;
- wherein the antibody or the functional fragment thereof is an antibody or a functional fragment thereof comprising an antibody light chain variable region (VL) having a complementarity determining region (CDR) L1 including an amino acid sequence having SEQ ID NO:
- 5, a complementarity determining region (CDR) L2 including an amino acid sequence having SEQ ID NO:
- 6, and a complementarity determining region (CDR) L3 including an amino acid sequence having SEQ ID NO:
- 7 and an antibody heavy chain variable region (VH) having a complementarity determining region (CDR) H1 including an amino acid sequence having SEQ ID NO:
- 8, a complementarity determining region (CDR) H2 including an amino acid sequence having SEQ ID NO:
- 9, and a complementarity determining region (CDR) H3 including an amino acid sequence having SEQ ID NO:
- 10;
- or
- an antibody or a functional fragment thereof comprising an antibody light chain variable region (VL) having a complementarity determining region (CDR) L1 including an amino acid sequence having SEQ ID NO:
- 21, a complementarity determining region (CDR) L2 including an amino acid sequence having SEQ ID NO:
- 22, and a complementarity determining region (CDR) L3 including an amino acid sequence having SEQ ID NO:
- 23 and an antibody heavy chain variable region (VH) having a complementarity determining region (CDR) H1 including an amino acid sequence having SEQ ID NO:
- 24, a complementarity determining region (CDR) H2 including an amino acid sequence having SEQ ID NO:
- 25, and a complementarity determining region (CDR) H3 including an amino acid sequence having SEQ ID NO:
- 26;
- or
- wherein the antibody or the functional fragment thereof is an antibody or a functional fragment thereof comprising a light chain variable region (VL) including an amino acid sequence having SEQ ID NO:
- 11 and a heavy chain variable region (VH) including an amino acid sequence having SEQ ID NO:
- 12;
- or
- an antibody or a functional fragment thereof comprising a light chain variable region (VL) including an amino acid sequence having SEQ ID NO:
- 27 and a heavy chain variable region (VH) including an amino acid sequence having SEQ ID NO:
- 28.
Dependencies are inferred from the claim text.