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AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsJoshua LaBaer, Lusheng Song, Ji Qiu, Yunro Chung
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Provided herein are methods, compositions, kits, and systems for detecting Epstein Barr virus infection (EBV) in gastric cancer (GC) patients. In particular, provided herein are methods, composition, kits, and systems for diagnosing and treating EBV-positive gastric cancer (EBV+ GC) in a biological sample of an individual based on the presence and level of antibodies against particular Epstein Barr virus proteins. EBV+ GC is a distinct subtype of gastric cancer and is associated with unique molecular profiles. Also provided herein are methods for providing more personalized therapy for each of these distinct cancer subtypes and methods for determining an Epstein Barr virus-positive gastric cancer antibody signature, and kits comprising components and protocols for performing the methods of this disclosure.
A method for identifying a subject having increased risk of developing Epstein-Barr Virus-positive gastric cancer (EBV+ GC), the method comprising:
A method to detect EBV+ GC in a subject at risk of having EBV+ GC, the method comprising:
A method of determining an Epstein Barr Virus (EBV) gastric cancer antibody signature comprising IgG antibodies, contained in a biological sample from an individual, that bind to immobilized EBV antigens, the method comprising:
Dependencies are inferred from the claim text.