Method of identifying pro-inflammatory dendritic cells
AssigneeAgency for Science, Technology and Research
InventorsFlorent Ginhoux, Charles Antoine Dutertre
Life of this patent
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Abstract
There is provided a method of identifying pro-inflammatory dendritic cells, the method comprising: determining an expression of CD5, CD14 and/or CD163 in cells, wherein CD5−, CD14+ and/or GD163+ cells are identified as pro-inflammatory dendritic cells. Also disclosed is a method of characterising inflammation and/or inflammatory disease in a subject, the method comprising: determining a proportion of CD5−, CD14+ and/or GD163+ dendritic cells in the subject's sample, wherein the proportion positively correlates with the level of inflammation and/or the severity of inflammatory disease in the subject.
Claims7
A method of characterising CD1c+ dendritic cells, the method comprising:
- determining an expression of one or more of CD5, CD14 and CD163 in the dendritic cells,
- wherein where the dendritic cells are determined to be CD5−, CD14+ and CD163+, identifying the dendritic cells as pro-inflammatory dendritic cells.
A kit for characterising CD1c+ dendritic cells, inflammation and/or inflammatory disease, the kit comprising reagents for detecting CD5, CD14 and CD163, wherein the kit further comprises methods for identifying dendritic cells to be pro-inflammatory dendritic cells where the dendritic cells are determined to be CD5−, CD14+ and CD163+.
Dependencies are inferred from the claim text.