Method, an electrochemical sensor and a system for selective detection of infections

A system for selective detection of infections, wherein the infections include at least a bacterial infection, the system comprising:

• a medical device;
• an electrochemical sensor including a solid substrate acting as a support, and an electrochemically active polymer deposited on top of said support and configured to be electrochemically activated, said electrochemical sensor, when in use, being adapted to be placed over a surface, part of the surface or in a body of said medical device;
• and
• a plurality of electrodes adapted and configured to apply an electrical potential to the electrochemically active polymer,
• wherein the medical device is configured to be located in a bacterial culture or located in a living tissue, and as a result of a cyclic voltammetry or chronoamperometry applied to the electrochemically active polymer, the electrochemically active polymer is configured to detect a concentration of nicotinamide adenine dinucleotide (NADH), and wherein the medical device comprises a suture, a surgical mesh, a vascular prosthesis, a hip prosthesis or a knee prosthesis
• wherein the electrochemically active polymer comprises:
• particles of amphiphilic copolymers consisting of a polythiophene backbone with grafted biocompatible polycaprolactone and polyethylene glycol blocks, or
• a layer of poly(hydroxymethyl-3,4-ethylenedioxythiophene) and a layer of poly(3,4-ethylenedioxythiophene), wherein the layer of poly(hydroxymethyl-3,4-ethylenedioxythiophene) is deposited on top of the solid substrate and the layer of poly(3,4-ethylenedioxythiophene) is deposited on top of the layer of poly(hydroxymethyl-3,4-ethylenedioxythiophene), wherein the solid substrate is a film of isotactic polypropylene.