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US 12,618,071 B2Granted
Multimeric oligonucleotides with divided strands
AssigneeMpeg La, LLC
InventorJonathan Miles Brown
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Abstract
The present disclosure relates to multimeric oligonucleotides comprising subunits, each of the subunits independently comprises a single-stranded or double-stranded oligonucleotide. Each of the subunits is joined to another subunit by a covalent linker, and at least one subunit comprises at least one partial single-stranded oligonucleotide. The present disclosure also relates to methods of synthesizing the multimeric oligonucleotides and the methods of using the multimeric oligonucleotides disclosed herein.
Claims14
A multimeric oligonucleotide comprising Structure 6:
- wherein:
- each is a single-stranded oligonucleotide, wherein each single-stranded oligonucleotide is 10-28 nucleotides in length;
- each is a partial single-stranded oligonucleotide, wherein each partial single-stranded oligonucleotide is 5-14 nucleotides in length;
- each • is a covalent linker;
- each is a complementary strand;
- and
- each of a, b, c, d, e, f, g, h, i, j, and k is independently an integer greater than or equal to zero, with the proviso that at least one of c, e, h, and j is greater than or equal to 1.
4 more elements
Dependencies are inferred from the claim text.