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US 12,618,066 B2Granted
Promoter having high activity in activated T-cell
AssigneeShanghai Cell Therapy Group Co., Ltd.
InventorsTao Liu, Yuan Fang, Haixia Gao, Qijun Qian
Life of this patent
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Abstract
Provided is a promoter having high activity in an activated T-cell. The promoter comprises, from 5′-end to 3′-end, a CMV enhancer, an IFNγ promoter, and a long terminal repeat sequence from human T-cell leukemia virus that are connected in sequence. The promoter exhibits greater activity in an activated immune cell than the existing promoters and is low in activity or inactive in other non-immune cells.
Claims18
A promoter comprising, from 5′-end to 3′-end, a CMV enhancer having the nucleotide sequence of SEQ ID NO:
- 8, an IFNY promoter having the nucleotide sequence of SEQ ID NO:
- 4, and a long terminal repeat sequence from human T-cell leukemia virus having the nucleotide sequence of SEQ ID NO:
- 3, which are connected in sequence.
Dependencies are inferred from the claim text.