Nucleic acid molecules
AssigneeCureVac AG
InventorsMariola Fotin-Mleczek, Katja Fiedler, Aleksandra Kowalczyk, Regina Heidenreich
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Abstract
The present invention provides novel artificial nucleic acid molecules encoding at least one antigenic peptide or protein and at least one additional sequence preferably targeting the antigenic peptides or proteins to cellular compartments of interest. Further, the invention provides (pharmaceutical) compositions or vaccines and kits comprising said nucleic acid molecules. The nucleic acid molecules, (pharmaceutical) compositions or vaccines and kits are useful for treating a variety of diseases such as cancer, infectious diseases, autoimmune diseases, allergies or graft-versus host disease.
Claims19
An artificial RNA molecule comprising at least one coding region encoding
- at least one antigenic protein comprising (i) at least one signal peptide, (ii) at least two epitopes from two different tumor antigens;
- (iii) a linker peptide linking said at least two epitopes,
- and (iv) at least one transmembrane domain from CTLA4 (Cytotoxic T-lymphocyte protein 4).
Dependencies are inferred from the claim text.