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US 12,618,059 B2Granted
Anc80 encoding sphingolipid-metabolizing proteins
AssigneeIcahn School of Medicine at Mount Sinai
InventorsEfrat Eliyahu, Adam Vincek, Michael Katz
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Abstract
The present disclosure pertains to the use of an Anc80 viral vector that encodes a sphingolipid-metabolizing protein such as acid ceramidase to achieve expression of the sphingolipid-metabolizing protein in a mammalian cell or group of cells. Expression of the protein from the Anc80 vector reduces high levels of ceramide in the cell that lead to cell death or senescence.
Claims5
A method to restore heart function in a subject following ischemia, reperfusion injury or myocardial infarction (MI), the method comprising:
- directly administering a therapeutically effective amount of an Anc80 viral vector comprising a nucleotide sequence encoding an acid ceramidase protein to cardiac cells of the subject in vivo, wherein the nucleotide sequence encoding the acid ceramidase is operatively linked to an expression control sequence.
Dependencies are inferred from the claim text.