Blends containing proteases

A solid composition obtained or obtainable by the steps of

• (a) preparing a first homogeneous solution of an acetate-free preparation of a neutral protease (NP) in an aqueous acetate-free low-salt solution, the aggregate concentration of salt(s) in said low-salt solution being in the range of about 1 mM to about 250 mM;
• (b) adding a neutral salt to the first homogeneous solution of step (a) and dissolving the neutral salt, thereby making a stabilized solution, wherein said stabilized solution additionally comprises a buffer salt buffering in the range of about pH 6 to about pH 8.5, and wherein the stabilized solution further comprises calcium chloride;
• (c) mixing the stabilized solution of step (b) with an acetate-free preparation of one or more proteolytic enzymes with collagenase activity (C), and making a second homogeneous solution;
• and
• (d) freeze-drying the solution of step (c), thereby obtaining the solid composition, wherein:
• the neutral protease is thermolysin;
• the neutral salt is sodium chloride;
• and
• a total protein content in the second homogeneous solution is in the range of 1 mg/ml to 150 mg/ml, a concentration of the calcium chloride is in the range of 1 mM to about 10 mM, and a concentration of sodium chloride in the second homogeneous solution is in the range of about 50 mM to about 500 mM.