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US 12,618,046 B2Granted
Generation of tumor immunity using astrocytes and astrocyte-dendritic cell combinations
OwnerJames Veltmeyerinventor
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Abstract
Disclosed are means, methods, and compositions of matter useful for treatment of oncological indications through stimulation of protective anti-cancer immunity. In one embodiment the invention discloses the unexpected effect of astrocytes to augment immune stimulating activities of dendritic cells. In one embodiment dendritic cells are pulsed with tumor lysates and subsequently co-cultured with astrocytes in the presence of toll-like receptor agonists.
Claims13
A method of treatment cancer comprising the steps of:
- a) obtaining a population of astrocyte cells;
- b) contacting said population of astrocyte cells with a population of dendritic cells;
- c) introducing one or more tumor antigens into said culture of astrocyte cells with dendritic cells;
- d) inducing maturation of said dendritic cells and e) administering said activated dendritic cells into a mammal in need of treatment.
1 more element
Dependencies are inferred from the claim text.