Product quality attribute measurement
AssigneeGenzyme Corporation
InventorsMarina Hincapie, Victoria Berger
Life of this patent
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Abstract
Systems for measuring a product quality attribute of an analyte of a biological sample include a first flow control device, a sample purification device, a second flow control device in fluid communication with first and second sample analyzers, where the first sample analyzer includes a first chromatography column, and a control unit configured so that during operation of the system, the control unit adjusts a configuration of the second flow control device to direct a portion of the biological sample to one of the first and second sample analyzers, and determines a product quality attribute of an analyte of the biological sample based on an analysis of the portion of the biological sample by the one of the first and second sample analyzers.
Claims22
A method for measuring product quality attributes of an analyte of a biological sample, the method comprising:
- obtaining a biological sample in a biological manufacturing system and delivering the biological sample to a first flow control device, wherein the first flow control device is configured to direct the biological sample either to a second flow control device or to a purification apparatus in fluid communication with the second flow control device;
- delivering the biological sample to the second flow control device, wherein the second flow control device is configured to receive the biological sample either directly from the first flow control device or from the purification apparatus;
- directing a first portion of the biological sample to a first sample analyzer via the second flow control device in fluid communication with the first flow control device, the purification apparatus, and the first sample analyzer, and obtaining information about a first product quality attribute of an analyte of the biological sample by analyzing the first portion of the biological sample in the first sample analyzer;
- directing a second portion of the biological sample to a second sample analyzer in fluid communication with the second flow control device and obtaining information about a second product quality attribute of an analyte of the biological sample by analyzing the second portion of the biological sample in the second sample analyzer,
- wherein the first and second product quality attributes are different.
Dependencies are inferred from the claim text.