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US 12,618,031 B2Granted
Delivery devices
AssigneeThe Methodist Hospital System
InventorsYing Xuan Chua, Alessandro Grattoni, Jesus Paez Mayorga, Simone Capuani
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Abstract
The present disclosure is directed to devices used for transplanting or recruiting cells, in addition to methods for making said devices and for using said devices in the treatment of medical disorders.
Claims20
A device comprising:
- a housing comprising a perimeter wall defining a cavity;
- and
- a support structure separating the cavity into a cell chamber and a reservoir chamber, the support structure comprises a nanoporous membrane for fluid communication between the cell chamber and the reservoir chamber;
- wherein the cell chamber has an outside surface that comprises at least one mesh layer;
- and
- wherein the outside surface of the cell chamber comprises at least 50% of the total outside surface of the device.
3 more elements
A device comprising:
- a housing comprising a perimeter wall defining a cavity;
- and
- a support structure separating the cavity into a cell chamber and a reservoir chamber;
- wherein the cell chamber comprises a cell population and vascularized tissue;
- wherein the reservoir chamber comprises one or more trophic factors;
- wherein the support structure comprises a membrane configured to homogenously deliver the one or more trophic factors to the cell population in the cell chamber;
- wherein the cell chamber has an outside surface that comprises at least one mesh layer;
- and
- wherein the outside surface of the cell chamber comprises at least 50% of the total outside surface of the device.
6 more elements
A device comprising:
- a housing comprising a perimeter wall defining a cavity;
- and
- a support structure separating the cavity into a cell chamber and a reservoir chamber;
- wherein the cell chamber comprises a cell population, one or more antigens, and vascularized tissue;
- wherein the reservoir chamber comprises one or more immune adjuvants;
- wherein the support structure comprises a membrane configured to homogenously deliver the one or more immune adjuvants to the cell population;
- wherein the cell chamber has an outside surface that comprises at least one mesh layer;
- and
- wherein the outside surface of the cell chamber comprises at least 50% of the total outside surface of the device.
6 more elements
Dependencies are inferred from the claim text.