Process for producing a composition comprising a crosslinked hydrogel

A process for producing a composition comprising a crosslinked hydrogel, the process comprising the steps of

• providing a container body, wherein the container body has a body inner wall and a body outer wall, wherein the body inner wall is configured to be tempered by means of temperature control arranged within a space defined between the body outer wall and the body inner wall of the container body,
• filling with a fluid comprising at least a mixture of a polymer and water into the container body,
• agitating the fluid,
• providing a container insert, the container insert having an insert outer wall which is configured to be tempered by means of temperature control arranged within a space defined within the insert outer wall of the container insert,
• forming a container assembly by inserting the container insert into the container body so that the insert outer wall of the container insert and the body inner wall of the container body are separated by a gap of constant width that defines a volume for receiving the fluid, and
• crosslinking the fluid while tempering the insert outer wall by the means of the temperature control arranged within the space defined within the insert outer wall of the container insert and, while tempering the body inner wall by the means of temperature control arranged within the space defined between the body outer wall and the body inner wall of the container body to form a crosslinked hydrogel, wherein the fluid is not agitated during the crosslinking to obtain the crosslinked hydrogel free of solid particles formed during the step of crosslinking.