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US 12,617,872 B2Granted
Heterodimeric human IgG1 polypeptides with isoelectric point modifications
AssigneeXencor, Inc.
InventorsGregory L. Moore, Gregory Lazar
Life of this patent
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Abstract
The invention relates generally to compositions and methods for purifying the desired species from a mixture of desired heterodimer and contaminating homodimer immunoglobulin variants by modifying the isoelectric point(s) of the individual chains.
Claims1
A composition comprising a variant human IgG1 heavy chain constant region comprising the amino acid substitutions L351K and T366K, wherein numbering is according to the EU index, and wherein the variant human IgG1 heavy chain constant region has at least 95% sequence identity to SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.