Anti-ADAMTS13 antibody and use thereof

An antibody or an antibody derivative thereof capable of binding to ADAMTS13 and having an inhibitory effect on von Willebrand factor (VWF) cleaving activity, comprising heavy chain and light chain complementarity determining regions selected from the group consisting of:

• (1) heavy chain complementarity determining regions CDR1 (GYSFTGYT, SEQ ID NO:
• 1), CDR2 (INPYNGGT, SEQ ID NO:
• 2), and CDR3 (ARTSGYLFAY, SEQ ID NO:
• 3), and
• light chain complementarity determining regions CDR1 (EDIYNR, SEQ ID NO:
• 4), CDR2 (GAT), and CDR3 (QQYWSSPLT, SEQ ID NO:
• 6);
• (2) heavy chain complementarity determining regions CDR1 (GFSLPRYG, SEQ ID NO:
• 7), CDR2 (IWAGGST, SEQ ID NO:
• 8), and CDR3 (ARAGGSQPFDY, SEQ ID NO:
• 9), and
• light chain complementarity determining regions CDR1 (RDINTY, SEQ ID NO:
• 10), CDR2 (RAN), and CDR3 (LQYDEFPWT, SEQ ID NO:
• 12);
• (3) heavy chain complementarity determining regions CDR1 (GFSLTRYG, SEQ ID NO:
• 13), CDR2 (IWAGGST, SEQ ID NO:
• 14), and CDR3 (ARAGGSSSFDY, SEQ ID NO:
• 15), and
• light chain complementarity determining regions CDR1 (QDINTY, SEQ ID NO:
• 16), CDR2 (RAN), and CDR3 (LQYDEFPWT, SEQ ID NO:
• 18);
• and
• (4) heavy chain complementarity determining regions CDR1 (GFSLTGYG, SEQ ID NO:
• 19), CDR2 (IWADGTT, SEQ ID NO:
• 20), and CDR3 (ARAGGSQPFDY, SEQ ID NO:
• 21), and
• light chain complementarity determining regions CDR1 (QDINSY, SEQ ID NO:
• 22), CDR2 (RAN), and CDR3 (LQYDEFPWT, SEQ ID NO:
• 24).