Back to results
US 12,617,866 B2Granted
Humanized antibodies to mucin-16 and methods of use thereof
AssigneesMemorial Sloan Kettering Cancer Center, Eureka Therapeutics, Inc.
InventorsDavid Spriggs, Dharmarao Thapi, Su Yan, Cheng Liu
Life of this patent
Estimating the term…
Abstract
Provided herein are compositions, methods, and uses involving anti-Mucin-16 (MUC16) agents that immunospecifically bind an epitope of Mucin-16 (MUC16). Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer and diseases associated with positive MUC16 expression.
Claims12
An anti-mucin 16 (MUC16) construct comprising an antibody moiety that immunospecifically recognizes a mucin 16 (MUC16) polypeptide, wherein the antibody moiety comprises:
- (a)
- (i) a variable heavy (VH) chain comprising SEQ ID NO:
- 4 or 5;
- and
- (ii) a variable light (VL) chain comprising SEQ ID NO:
- 2 or 3;
- or
- (b)
- (i) a variable heavy (VH) chain comprising SEQ ID NO:
- 22 or 23;
- and
- (ii) a variable light (VL) chain comprising SEQ ID NO:
- 20 or 21,
- wherein the VH chain and VL chain are humanized.
11 more elements
Dependencies are inferred from the claim text.