Human broadly neutralizing antibodies against the membrane-proximal external region of HIV Env for vaccine design and intervention
AssigneeThe Scripps Research Institute
InventorsMichael Zwick, Lei Zhang, Adriana Irimia, Jiang Zhu, Ian Wilson
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Abstract
The present disclosure relates to anti-HIV antibodies and their use in the treatment or prevention of HIV/AIDS and in the development of HIV vaccines.
Claims17
An isolated monoclonal antibody or antigen-binding fragment thereof that binds Human Immunodeficiency Virus (HIV) envelope glycoprotein (Env) membrane-proximal external region (MPER) and comprises a heavy chain variable region (VH) comprising a VH CDR1, VH CDR2, and VH CDR3 and a light chain variable region (VL) comprising a VL CDR1, VL CDR2, and VL CDR3, wherein the VH CDR1, VH CDR2, VH CDR3, VL CDR1, VL CDR2, and VL CDR3 comprise the amino acid sequence of
- (a) SEQ ID NO:
- 61, 62, 63, 70, 71, and 72, respectively, or
- (b) SEQ ID NO:
- 64, 65, 66, 73, 74, and 75, respectively,
- wherein the HIV Env MPER comprises the amino acid sequence of DLLALDRWQNLWNWFDITNWLWYIK (SEQ ID NO:
- 2).
Dependencies are inferred from the claim text.