Nucleic acid antibody constructs for use against respiratory syncytial virus
AssigneeThe Wistar Institute of Anatomy and Biology
InventorsDavid Weiner, Kar Muthumani, Jing Chen, Trevor Smith, Katherine Schultheis
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Abstract
Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Respiratory Syncytial Virus antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Respiratory Syncytial virus infection in a subject using the composition and method of generation.
Claims8
A composition comprising a nucleic acid molecule encoding a synthetic antibody and hyaluronidase, wherein the nucleic acid molecule comprises a nucleotide sequence encoding ScFv anti-RSV-F synthetic antibody, wherein the nucleic acid molecule comprises nucleotides 742-2220 of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.