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AssigneeZhejiang University
InventorsJiyong Zhou, Min Liao, Yan Yan, Boli Hu, Jinyan Gu, Xiaojuan Zheng, Weiren Dong, Yulan Jin
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The present invention is a hybridoma cell line for secreting monoclonal antibody against rabies virus M protein and its application, relates to the field of biotechnology. A classification of the hybridoma cell line is named as hybridoma cell line 4A1, and the hybridoma cell line was deposited on Apr. 1, 2019 in the China Center for Type Culture Collection, Wuhan University, Wuhan, China, with a deposit number CCTCC NO: C201947. The monoclonal antibody prepared by the hybridoma cell line has high titer, good specificity and excellent biological characteristics. The present invention identifies the variant antigen epitope recognized by the RABV M protein, the hybridoma cell line can be used to distinguish Flury strain and other RABV strains, prepare kit for detecting rabies virus RABV, detect RABV infection and differential diagnosis vaccine Flury strain and other RABV strains.
A hybridoma cell line for secreting a monoclonal antibody against rabies virus M protein, wherein the classification designation of the hybridoma cell line is Hybridoma cell line 4A1 with a deposit number of the Hybridoma cell line China Center for Type Culture Collection (CCTCC) NO:
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