Genetically modified immune cell, preparation method therefor, and application
AssigneeShenzhen In Vivo Biomedicine Technology Limited Company
InventorsPeng Li, Zhiwu Jiang, Zhaoyang Tang, Rui Liao, Xiaohan Huang, Simiao Lin, Suna Wang, Youguo Long, Qiting Wu, Yao Yao
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Abstract
Provided are a genetically modified immune cell, a preparation method therefor, and an application. The immune cell overexpresses HIL-6 and/or L-GP130. HIL-6 or L-GP130 continuous overexpression/conditionally induced overexpression in the immune cell reduces the side effects of CAR-T therapy while maintaining immune and anti-tumour effects, and has potential value in the treatment of malignant tumours and AIDS.
Claims11
An immune cell overexpressing HIL-6 and L-GP130, wherein the HIL-6 has an amino acid sequence of SEQ ID NO:
- 1, wherein the L-GP130 has an amino acid sequence of SEQ ID NO:
- 3, wherein the immune cell is a T cell and wherein the T cell is modified with a CAR molecule.
Dependencies are inferred from the claim text.