Self-assembling peptide
AssigneesNational University Corporation Tokyo Medical and Dental University, Kanagawa Institute of Industrial Science and Technology
InventorsTakahiro Muraoka, Atsuya Yaguchi, Itsuki Ajioka, Go Watanabe
Life of this patent
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Abstract
An object is to provide a peptide gelling agent which gels under physiological conditions and which has a relatively short chain length, and a sustained-release gel based on the gelling agent. A hydrogelling self-assembling peptide is provided having one or two core peptides with an amino acid sequence of the formula: Xaa-Yaa-Zaa-Yaa-Xaa-Yaa-Zaa-Yaa-Xaa, wherein Xaa is independently Ile or Met, Yaa is independently Asp, Glu, Lys, or Arg, and Zaa is independently Ala or Gly. The full length of the amino acid sequence constituting the self-assembling peptide is 25 amino acids or less.
Claims24
A hydrogelling self-assembling peptide selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 41, SEQ ID NO:
- 42, SEQ ID NO:
- 43, SEQ ID NO:
- 44, and SEQ ID NO:
- 45.
A composition for preparing a sustained-release gel, comprising a gelling agent consisting of a first self-assembling peptide, and a functional molecule formed by linking a second self-assembling peptide and a functional moiety,
- wherein said first and second self-assembling peptides are selected from the group consisting of SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 41, SEQ ID NO:
- 42, SEQ ID NO:
- 43, SEQ ID NO:
- 44, and SEQ ID NO:
- 45,
- wherein said functional moiety is a functional peptide and/or a low molecular weight compound.
A fusion molecule formed by linking a self-assembling peptide and a functional moiety, wherein said self-assembling peptide is selected from the group consisting of SEQ ID NOs:
- SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, SEQ ID NO:
- 7, SEQ ID NO:
- 8, SEQ ID NO:
- 9, SEQ ID NO:
- 10, SEQ ID NO:
- 11, SEQ ID NO:
- 12, SEQ ID NO:
- 41, SEQ ID NO:
- 42, SEQ ID NO:
- 43, SEQ ID NO:
- 44, and SEQ ID NO:
- 45, and wherein said functional moiety is a functional peptide and/or a low molecular weight compound.
Dependencies are inferred from the claim text.