Engineered viral capsid polypeptides and uses thereof
AssigneePresident and Fellows of Harvard College
InventorsEric Kelsic, Sam Sinai, Pierce Ogden, George M. Church
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Abstract
The technology described herein provides variant adeno-associated viral capsid polypeptides and viruses comprising the same. Such variant viral capsid polypeptides bear a mutation relative to SEQ ID NO: 2 (WT AAV2) in a region corresponding to amino acids 561-588, wherein the region corresponding to amino acids 561-588 comprises a sequence selected from SEQ ID NO: 4-41,337. Further provided herein are methods for delivering a viral payload using viruses comprising variant capsid polypeptides described herein.
Claims18
A viral capsid polypeptide bearing a mutation relative to SEQ ID NO:
- 2 (WT AAV2) in a region corresponding to amino acids 561-588, wherein the region corresponding to amino acids 561-588 comprises a sequence selected from SEQ ID NO:
- 4-41,337.
An AAV2 capsid polypeptide comprising a sequence of SEQ ID NO:
- 2, wherein the region of amino acids 561-588 of SEQ ID NO:
- 2 comprises a variant sequence selected from SEQ ID NO:
- 4-41,337.
Dependencies are inferred from the claim text.