Dihydro-cyclopenta-isoquinoline sulfonamides derivatives

A compound of general formula (I) or a pharmaceutically acceptable salt thereof,

• Wherein:
• X is C or N,
• Y is C or O,
• When Y is O, R1 is hydrogen or hydroxy, R1′ is hydrogen and R2 and R2′ are absent;
• R1 represents
• Hydrogen;
• Hydroxy;
• An oxo group;
• Amino;
• C1-6-alkyl;
• C1-6-alkylamino;
• C(O)OH;
• C(O)NH-Heteroaryl;
• —NH—C1-6-alkyl-C3-6-cycloalkyl;
• —NH—C1-6-alkyl-C(O)OH optionally substituted with an amino group;
• —NH-cycloalkyl optionally substituted with one or more groups which are independently halogen;
• oxo;
• C1-6-alkyl;
• C1-6-alkylamino;
• C1-6-alkyl-C1-4-alkylamino;
• C3-8-cycloalkyl-C1-6-alkylamino;
• heteroaryl;
• or heteroarylamino optionally substituted with one or more C1-6-alkyl;
• Heteroaryl optionally substituted with one or more groups which are independently Halogen;
• hydroxy;
• oxo;
• amino;
• cyano;
• —C(O)—C1-6-alkyl;
• C1-6-alkyl;
• C1-6-alkylamino;
• C1-6-alkoxy;
• —NH—(C1-6-alkyl)-heterocycloalkyl;
• —NH—(C1-6-alkyl)-heteroaryl optionally substituted with one or more C1-6-alkyl;
• —NH—C1-6-alkyl-cycloalkyl;
• —NH—C(O)-cycloalkyl;
• —NH-heteroaryl substituted with one or more C1-6-alkyl;
• or —NH—C1-6-alkyl-C(O)OH;
• Heteroaryl substituted with heteroarylamino optionally substituted with C1-6-alkyl;
• C1-6-alkoxy;
• C3-6-cycloalkyl;
• C1-6-haloalkoxy, C1-6-haloalkyl;
• CN, halogen;
• C(O)OH, or —C(O)O—C1-6-alkyl;
• —NH—C(S)—NH—Ra1;
• —NH—SO2-Rb1;
• —NH-heteroaryl optionally substituted with one or more groups which are independently oxo;
• C1-6-alkyl;
• C1-6-alkylamino;
• heteroaryl optionally substituted with one or more oxo;
• C1-6-alkyl;
• —C(O)—NHNH—C(O)CH3;
• aryl;
• heteroarylamino;
• C1-6-alkoxy;
• C3-6-cycloalkyl;
• C1-6-haloalkoxy, C1-6-haloalkyl;
• CN, halogen;
• C(O)OH, or —C(O)O—C1-6-alkyl;
• —NH-heterocycloalkyl optionally substituted with one or more groups which are independently Halogen;
• C1-6-alkyl;
• oxo;
• heteroaryl;
• C(O)ORb1;
• C1-6-alkyl-NRb1Rb1;
• NHC(O)-aryl;
• or NHC(O)-heteroaryl;
• —NH—C1-6-Alkyl substituted with one heteroaryl group optionally substituted with one or more groups which are independently C1-6-alkyl or amino;
• —NH—C(O)O—Rb1;
• NH—C(NCN)—NH—Ra1;
• —NH—C(NCN)—NH-Heteroaryl;
• —NH—C(O)—C3-8-heterocycloalkyl-C(O)O—Rb1;
• —C(O)NH—C1-6-alkyl;
• —NH—C(O)NH—C1-6-alkyl optionally substituted with one or more C3-8-heterocyclolakyl;
• —NH—C(O)NH-heterocycloalkyl-C1-6-alkyl;
• —NH—C1-6-alkyl-C(O)—C1-6-alkylamino;
• Heteroaryloxy;
• —NH—C(O)-aryl;
• —NH—C(O)-heteroaryl;
• —NH—C(O)-heterocycloalkyl;
• —NH—C(O)—C1-6-alkyl optionally substituted with one or more amino group;
• —NH—C(O)—C1-6-alkyl-C(O)ORb1 optionally substituted with amino;
• —NH—C(O)ORb1
• Heterocycloalkyl optionally substituted with one or more groups which are independently amino;
• —C(O)NH—Rb1;
• —C(O)ORb1;
• —NHC(O)-heteroaryl optionally substituted with one or more C1-6-alkyl;
• —NHC(O)—C1-6-alkyl optionally substituted with an amino group;
• or —NHC(O)O—C1-6-alkyl;
• —NH—C(O)Rb1;
• or —C2-6-alkene group optionally substituted with one or more groups which are halogen;
• or ═NH group;
• Ra1 represents
• C1-6-alkyl;
• Aryl optionally substituted with one or more C1-6-alkyl;
• or
• Heteroaryl optionally substituted with one or more C1-6-alkyl;
• Rb1 represents
• Hydrogen;
• C1-6-alkyl;
• or
• Aryl optionally substituted with one or more halogen;
• C1-6-alkyl;
• or
• hydroxy;
• R1′ represents
• hydrogen;
• or
• hydroxy;
• R2 represents
• hydrogen;
• Halogen;
• A hydroxy group;
• An oxo group;
• C1-6-alkyl;
• C3-8-heterocycloalkyl optionally substituted with one or more hydroxy;
• Halogen;
• amino;
• amino-C-1-6-alkyl;
• C1-6-alkyl;
• C(O)O—C1-6-alkyl;
• or C(O)NH2;
• Heteroaryl optionally substituted with one or more groups which are independently C1-6-alkylamino;
• heteroaryl optionally substituted with one or more C1-6-alkyl;
• halogen;
• Heteroaryl optionally substituted with —NH-heteroaryl optionally substituted with one or more C1-6-alkyl;
• halogen;
• cyano;
• —C(O)OH;
• —C(O)O—C1-6-alkyl, C1-6-haloalkyl;
• C1-6-alkoxy;
• C1-6-haloalkoxy;
• or C3-6-cycloalkyl;
• —NH-cycloalkyl optionally substituted with one or more groups which are independently halogen;
• oxo;
• C1-6-alkyl;
• C1-6-alkylamino;
• C1-6-alkyl-C1-4-alkylamino;
• C3-8-cycloalkyl-C1-6-alkylamino;
• aryl;
• heteroaryl;
• or heteroarylamino optionally substituted with one or more C1-6-alkyl;
• —NH-heteroaryl optionally substituted with one or more groups which are independently hydroxy;
• halogen;
• oxo;
• C1-6-alkyl;
• C1-6-alkoxy;
• heteroaryl optionally substituted with one or more hydroxy;
• Halogen;
• oxo;
• C1-6-alkyl;
• C(O)O—C1-6-alkyl;
• C(O)OH;
• C1-6-haloalkyl;
• C1-6-alkoxy;
• C1-6-haloalkoxy;
• C3-6-cycloalkyl;
• C1-6-alkylamino;
• cyano;
• or heterocycloalkyl substituted with one or more hydroxy Halogen;
• oxo group;
• —NH—C1-6-Alkyl substituted with one heteroaryl group optionally substituted with one or more independently selected C1-6-alkyl groups;
• —NH—SO2-Heteroaryl optionally substituted with one or more halogen;
• —NHC(O)—C1-6-alkyl optionally substituted with one or more halogen;
• C1-6-alkoxy;
• amino;
• C3-8-cycloalkyl;
• C3-8-heterocycloalkyl;
• or heteroaryl;
• —NHC(O)-heteroaryl optionally substituted with one or more groups which are independently halogen;
• hydroxy;
• oxo;
• C1-6-alkyl;
• heteroaryl;
• C1-6-alkylamino;
• S(O)2-C1-3-alkyl;
• or —NHC(O)—C1-6-alkyl;
• —NHC(O)—C3-8-heterocycloalkyl optionally substituted with one or more oxo;
• or C1-6-alkyl;
• —NHC(O)O—C1-6-alkyl;
• —NHC(O)O—C1-6-alkyl-Ra2;
• —NHC(O)O-aryl;
• —NHC(O)NH—Ra2;
• —NHC(O)NH—C1-6-alkyl-Ra2;
• —NH—C(NCN)—NH—Ra1;
• —NHC(O)—C3-8-cycloalkyl;
• —NH—SO2—Rb2;
• —NH—C(S)—NH—Rb2;
• —NH—C3-8-heterocycloalkyl optionally substituted with one or more groups which are independently oxo;
• or C1-6-alkyl;
• An Aryloxy group;
• or
• Heteroaryloxy group;
• Ra2 represents
• Hydrogen;
• Aryl optionally substituted with one or more groups which are independently halogen;
• hydroxy;
• oxo;
• or C1-6-alkyl;
• Heteroaryl optionally substituted with one or more groups which are independently halogen;
• hydroxy;
• oxo;
• or C1-6-alkyl;
• Rb2 represents
• C1-6-alkyl;
• or
• Heteroaryl;
• R2′ represents
• hydrogen;
• or
• hydroxy;
• R3 represents
• C1-6-alkyl optionally substituted with one or more independently selected R3a groups;
• C1-3-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more independently selected R3a groups;
• C1-3-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more independently selected R3a groups;
• C3-6-heterocycloalkyl optionally substituted with one or more independently selected R3a groups;
• or
• C3-6-cycloalkyl optionally substituted with one or more independently selected R3a groups;
• R3a represents hydrogen;
• Halogen;
• C1-2-alkyl;
• hydroxy;
• or C1-2-alkoxy;
• R4 represents:
• C3-6-cycloalkyl optionally substituted with one or more R4a group;
• or C1-6-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more R4a group;
• or C1-6-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more R4a group;
• R4a represents a group which are independently hydroxy;
• Halogen;
• or C1-2-alkyl;
• and
• R5 represents
• Hydrogen, methyl or halogen;
• With the proviso that:
• when R1′ is hydroxy, then R1 is pyridyl or C1-6-alkyl;
• when R2′ is hydroxy, then R2 is pyridyl or C1-6-alkyl;
• when R1 is different than hydrogen, then R2 and R2′ are hydrogen;
• when R2 is different than hydrogen, then R1 and R1′ are hydrogen;
• when R1 is oxo, R1′ is absent;
• and
• when R2 is oxo, R2′ is absent.