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US 12,617,784 B2Granted
AKT inhibitor
AssigneeNanjing Chia Tai Tianqing Pharmaceutical Co., Ltd.
InventorsChangyou Ma, He Tian, Jie An, Jianliang Zhao, Donghui Chen, Jian Wu, Dan Xu, Chunxia Zhu, Zhoushan Tian
Life of this patent
Estimating the term…
Abstract
An AKT inhibitor is provided, which specifically relates to a compound represented by formula I or a pharmaceutically acceptable salt thereof. The present invention further provides a preparation method thereof, and the use thereof in prevention and/or treatment of a disease mediated by AKT protein kinase.
Claims22
A compound represented by formula I or a pharmaceutically acceptable salt thereof,
- wherein
- R1 is selected from the group consisting of H and C1-C6 alkyl, wherein the C1-C6 alkyl is optionally substituted by halogen or OH;
- R2 and R3 are each independently selected from the group consisting of H, C1-C6 alkyl, and C3-C6 cycloalkyl;
- or
- R1 and R2, together with the atoms to which R1 and R2 are attached, form a 4-7 membered nitrogen-containing heterocyclic ring;
- m is 1 or 2, n is 0;
- R4 and R5 form ═O together;
- is selected from the group consisting of
- R6, R7, R8, and R9 are each independently selected from the group consisting of H and C1-C6 alkyl, wherein the C1-C6 alkyl is optionally substituted by halogen;
- R10 is H or C1-C6 alkyl, wherein the C1-C6 alkyl is optionally substituted by halogen, OH or CN;
- L is selected from the group consisting of
- and is optionally substituted by one or more R12;
- wherein a single wavy line is a position where L is connected to carbonyl, and a double wavy line is a position where L is connected to pyrimidine;
- and wherein R12 is C1-C6 alkyl;
- G is a 6-10 membered aryl optionally substituted by 1-5 R11;
- R11 is halogen;
- provided that neither R1 nor R2 is H if R1 and R2, together with the atoms to which R1 and R2 are attached, form a 4-7 membered nitrogen-containing heterocyclic ring;
- and
- when L is
- is not
17 more elements
A compound selected from the group consisting of:
Dependencies are inferred from the claim text.