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US 12,617,775 B2Granted
Processes of making CSF-1R inhibitors and methods of use thereof
AssigneeDeciphera Pharmaceuticals, LLC
InventorsElena Kostik, Ann Gelormini, Michael D. Kaufman
Life of this patent
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Abstract
The present disclosure relates to processes of making a compound represented by Formula (I) and methods of use thereof.
Claims8
A dihydrate form of the compound of Formula (II):
- prepared by a process comprising:
- reacting a compound of Formula (IX):
- with a compound of Formula (XII):
- in the presence of a first catalyst to produce a compound of Formula (IV):
- reacting the compound of Formula (IV) with a compound represented by:
- in the presence of a second catalyst, to produce a compound of Formula (III):
- and
- reacting the compound of Formula (III) with isopropylamine,
- thereby preparing the compound of Formula (II).
6 more elements
Dependencies are inferred from the claim text.