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US 12,617,762 B2Granted
Carboxy derivatives with antiinflamatory properties
AssigneeSitryx Therapeutics Limited
InventorsMichael Liam Cooke, David Cousin, Matthew Colin Thor Fyfe, Thomas Michael Waugh, Saleh Ahmed, Alessio De Simone, Barry John Teobald
Life of this patent
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Abstract
The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: (I) wherein, RA1, RA2, RC and RD are as defined herein.
Claims21
A compound of formula (I):
- wherein,
- represents a 5 membered heteroaryl ring, which in addition to the C═N shown contains one or more further heteroatoms independently selected from the group consisting of N, O and S;
- or
- represents a 6 membered heteroaryl ring, which in addition to the C═N shown optionally contains one or more further N atoms;
- RA1 is (CH2)0-2-phenyl;
- wherein RA1 is optionally substituted by one or more substituents selected from the group consisting of halo, C1-6 alkyl, C1-6 haloalkyl, hydroxy, cyano, OG1, S(O)0-2G1, SF5, (CH2)0-3C3-7 cycloalkyl and 5-7-membered heterocyclyl wherein said C3-7 cycloalkyl and said 5-7-membered heterocyclyl are optionally substituted by one or more groups selected from the group consisting of halo, C1-3 alkyl and C1-3 haloalkyl;
- wherein two alkyl groups which are attached to the same carbon atom are optionally joined to form a C3-7 cycloalkyl ring;
- wherein the C3-10 cycloalkyl group is optionally fused to a phenyl ring which phenyl ring is optionally substituted by one or more halo atoms;
- or RA1 is optionally substituted by one phenyl ring which is optionally substituted by C1-2 haloalkyl, C1-2 haloalkoxy or one or more halo atoms;
- wherein G1 is C1-6 alkyl, C3-7 cycloalkyl, C1-6 haloalkyl, or (CH2)0-1phenyl wherein G1 is optionally substituted by one or more substituents selected from the group consisting of halo, C1-2 alkyl, C1-2 haloalkyl, hydroxy, cyano, nitro, C1-2 alkoxy and C1-2 haloalkoxy;
- RA2 is selected from the group consisting of halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, hydroxy, cyano, nitro, NR1R2, OG2 and S(O)0-2G2;
- wherein G2 is C1-6 alkyl, C3-7 cycloalkyl, C1-6 haloalkyl, or phenyl which is optionally substituted by one or more substituents selected from the group consisting of halo, C1-2 alkyl, C1-2 haloalkyl, hydroxy, cyano, nitro, C1-2 alkoxy and C1-2 haloalkoxy;
- and
- wherein R1 and R2 are independently H or C1-2 alkyl or, taken together, R1 and R2 may combine to form a 5-7-membered heterocyclic ring;
- or RA2 is absent;
- and
- RC and RD are each independently H, C1-2 alkyl, hydroxy, fluoro or C1-2 alkoxy;
- or RC and RD may join to form a C3-5 cycloalkyl ring;
- and wherein
- the total number of carbon atoms in groups RA1 and RA2 taken together including their optional substituents is 6-14;
- or a pharmaceutically acceptable salt and/or solvate thereof.
18 more elements
Dependencies are inferred from the claim text.