Modifier of four-membered ring derivative, preparation method and application thereof
AssigneesShanghai Hansoh Biomedical Co., Ltd., Jiangsu Hansoh Pharmaceutical Group Co., Ltd.
InventorsYidong Su, Xiaofeng Mao, Kailong Li, Jun Wang, Jiaqiang Cai, Rudi Bao
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Abstract
Provided is a modifier of a four-membered ring derivative, a preparation method and application thereof. In particular, provided is a compound represented by the general formula (IX-A), a preparation method thereof, a pharmaceutical composition containing the compound, and a use thereof as a G protein-coupled receptor modulator in the treatment or prevention of central nervous system diseases and/or mental diseases. The definition of each substituents in the general formula (IX-A) is same as the definition in the specification.
Claims20
A compound of formula (IX-A), a stereoisomer thereof or a pharmaceutically acceptable salt thereof,
- wherein:
- R4 is selected from the group consisting of 5 to 6 membered N-containing heterocyclyl,
- Ra is selected from the group consisting of hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, C1-6 alkyl, C1-6 deuterated alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, 3 to 8 membered heterocyclyl, C6-12 aryl and 5 to 12 membered heteroaryl;
- Rb is selected from the group consisting of hydrogen, deuterium, halogen, amino, nitro, hydroxy, cyano, C1-6 alkyl, C1-6 deuterated alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 hydroxyalkyl, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, 3 to 8 membered heterocyclyl, C6-12 aryl and 5 to 12 membered heteroaryl, wherein the amino, C1-6 alkyl, C1-6 deuterated alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, 3 to 8 membered heterocyclyl, C6-12 aryl and 5 to 12 membered heteroaryl are each optionally further substituted by one or more substituents selected from the group consisting of deuterium, halogen, amino, nitro, hydroxy, cyano, C1-6 alkyl, C1-6 deuterated alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, 3 to 8 membered heterocyclyl, C6-12 aryl and 5 to 12 membered heteroaryl;
- R5 is selected from the group consisting of hydrogen, deuterium, C1-6 alkyl, C1-6 deuterated alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, halogen, amino, nitro, hydroxy, cyano, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, 3 to 8 membered heterocyclyl, C6-12 aryl and 5 to 12 membered heteroaryl;
- or, any adjacent two R5 are bonded to form a 5 to 6 membered heterocyclyl or 5 to 6 membered heteroaryl;
- r is 0, 1 or 2;
- m is 0 or 1;
- and
- t is 0, 1, 2 or 3;
- when
- and m is 1,
- then R4 is not
- —NHC(O)C2H5, —NHC(O)N(CH3)2, —NHC(O)NHCH3, —NHC(O)N(C2H5)CH3, —NHC(O)NHC2H5,
- when m is 2, then R4 is not —NHC(O)N(CH3)2.
A compound of formula (XII-1), a stereoisomer thereof or a pharmaceutically acceptable salt thereof,
Dependencies are inferred from the claim text.