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US 12,617,758 B2Granted
Quinazoline derivative having FLT3 inhibitory activity, and use thereof
AssigneeIndustry-University Cooperation Foundation Hanyang University Erica Campus
InventorsJung-Mi Hah, Da Seul Im
Life of this patent
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Abstract
The present invention relates to a novel quinazoline derivative having fms-like tyrosine kinase 3 (FLT3) inhibitory activity, and a use thereof. A novel quinazoline derivative or a pharmaceutically acceptable salt thereof, according to the present invention, exhibits excellent inhibitory activity against FLT3, and thus targeted treatment through more fundamental approaches is expected in the prevention or treatment of acute myeloid leukemia (AML).
Claims13
A compound of the following Chemical Formula 7 or a pharmaceutically acceptable salt thereof:
- wherein, in Chemical Formula 7,
- R1 is
- R2 is selected from the group consisting of indazolyl, naphthalenyl, dihydrobenzofuranyl, pyridinyl, acetyl piperidine, phenyl which is unsubstituted or substituted with one or more non-hydrogen substituents, pyrazolyl which is unsubstituted or substituted with one or more non-hydrogen substituents, dihydroisoxazole which is unsubstituted or substituted with one or more non-hydrogen substituents,
- or a C3-C7 cycloalkyl, the non-hydrogen substituent in R2 is selected from the group consisting of
- phenyl, hydroxy, a C1-C6 alkyl, a C1-C6 halogenated alkyl, or a halogen atom,
- R3 is a hydrogen atom, hydroxy, a C1-C6 alkyl or a C1-C6 halogenated alkyl,
- R4 is a hydrogen atom, hydroxy or a C1-C6 alkyl, or is absent, here, X is a nitrogen or oxygen atom, and Y is a halogen or oxygen atom,
- R5 is a hydrogen atom, hydroxy, a halogen atom or a C1-C6 halogenated alkyl,
- R6 is a hydrogen atom, hydroxy or a C1-C6 alkyl, and
- a connecting line expressed as a double line () of a solid line and a dotted line represents a single carbon-carbon bond or a double carbon-carbon bond.
7 more elements
Dependencies are inferred from the claim text.