Rapidly metabolized lipid compound

A compound of formula (I), or a pharmaceutically acceptable salt, isotopic variant, tautomer, or stereoisomer thereof:

• wherein,
• G1 and G2 are independently selected from a chemical bond, C1-13 linear alkylene, C2-13 linear alkenylene, and C2-3 linear alkynylene, each of which is optionally substituted with one or more RG1;
• G1 and G2 have a total length of 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, or 13 carbon atoms;
• RG1 is independently H, C1-14 alkyl, —La-ORa, La-SRa, or -La-NRaR′a;
• G3 is C4-14 linear alkylene, C4-14 linear alkenylene, or C4-14 linear alkynylene, each of which is optionally substituted with one or more R3;
• RG3 is independently —H, -La-ORa, -La-SRa, or -La-NRaR′a;
• La is independently a chemical bond or C1-4 alkylene;
• Ra and R′a are independently selected from H, C1-14 alkyl, C3-14 cycloalkyl, and 3- to 14-membered heterocyclyl;
• G4 is a chemical bond, C1-6 alkylene, C2-6 alkenylene, or C2-6 alkynylene, each of which is optionally substituted with one or more RG4;
• RG4 is independently H, C1-6 alkyl, -Lb-ORb, -Lb-SRb, or -Lb-NRbR′b;
• Lb is independently a chemical bond or C1-6 alkylene;
• Rb and R′b are independently selected from H, and C1-6 alkyl;
• or, two RG4 attached to the same carbon atom are taken together with the carbon atom to which they are attached to form C3-14 cycloalkylene or 3- to 14-membered heterocyclylene, each of which is optionally substituted with one or more R4g;
• R4g is independently H, halogen, cyano, C1-8 alkyl, C1-8 haloalkyl, -Le-ORe, -Le-SRe, or -Le-NReR′e;
• Le is independently a chemical bond or C1-8 alkylene;
• Re and R′e are independently selected from H, C1-8 alkyl, C3-14 cycloalkyl, and 3- to 14-membered heterocyclyl;
• M1 and M2 are independently selected from —C(O)O—, —OC(O)—, —O—, —SC(O)O—, —OC(O)NR—, —NRC(O)NR—, —OC(O)S—, —OC(O)O—, —NRC(O)O—, —SC(O)—, —C(O)S—, —NR—, —C(O)NR—, —NRC(O)—, —NRC(O)S—, —SC(O)NR—, —C(O)—, —OC(S)—, —C(S)O—, —OC(S)NR—, —NRC(S)O—, —S—S—, and —S(O)0-2—;
• Q is selected from a chemical bond, —C(O)O—, —O—, —SC(O)O—, —OC(O)NRf—, —NRfC(O)NRf—, —OC(O)S—, —OC(O)O—, —NRfC(O)O—, —OC(O)—, —SC(O)—, —C(O)S—, —NRf—, —C(O)NRf—, —NRfC(O)—, —NRC(O)S—, —SC(O)NRf—, —C(O)—, —OC(S)—, —C(S)O—, —OC(S)NRf—, —NRfC(S)O—, —S—S—, —S(O)0-2—, phenylene, and pyridinylene;
• R1s independently selected from H, and C1-10 alkyl;
• R1 and R2 are independently selected from C4-20 alkyl, C4-20 alkenyl, and C4-20 alkynyl, each of which is optionally substituted with one or more R1s and wherein one or more methylene units are optionally and independently replaced with —NR′—;
• R1s is independently H, C1-20 alkyl, -Lc-ORc, -Lc-SRc, or -Lc-NRcR′c;
• R and R′ are independently H or C1-20 alkyl;
• Le is independently a chemical bond or C1-20 alkylene;
• Rc and R′c are independently selected from H, C1-20 alkyl, C3-14 cycloalkyl, and 3- to 14-membered heterocyclyl;
• R3 is selected from CN, —ORg, —C(O)Rg, —OC(O)Rg, —NR″C(O)Rg, —NRgR′g, —NR″C(O)NRgR′g, —NR″C(O)Rg, —NR″S(O)2Rg, —OC(O)NRgR′g, —NR″C(O)ORg, —N(ORg)C(O)Rg, —N(ORg)S(O)2Rg, —N(ORg)C(O)ORg, —N(ORg)C(O)RgR′g, 3- to 14-membered heterocyclyl, and 5- to 14-membered heteroaryl;
• Rg and R′g are independently H, C1-10 alkyl, C3-10 cycloalkyl, or 3- to 10-membered heterocyclyl;
• R″ is independently H or C1-6 alkyl;
• R4 and R5 are independently C1 alkyl;
• or, R4 and R5 are taken together with the carbon atom to which they are attached to form C3a cycloalkylene or 3- to 6-membered heterocyclylene.