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US 12,617,747 B2Granted
Cannabinoid analogs and methods for their preparation
AssigneeInmed Pharmaceuticals Inc.
InventorsPhilip J. Barr, Charles K. Marlowe, Jianping Sun, James T. Kealey
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Abstract
Provided herein are cannabinoid analogs, including halogenated cannabinoid analogs, hydroxylated cannabinoid analogs, deuterated cannabinoid analogs, and tritiated cannabinoid analogs. The cannabinoid analogs can be prepared by partial or total expression in modified host cells, such as recombinantly modified yeast cells, optionally in combination with chemical synthetic steps.
Claims16
A pharmaceutical composition comprising a compound according to Formula I:
- or a salt or cannabinoid derivative thereof, wherein:
- R1 is selected from the group consisting of C1-C20 haloalkyl, C1-C20 hydroxyalkyl, C2-C20 alkenyl, deuterated C1-C20 alkyl, and tritiated C1-C20 alkyl,
- R2 is selected from the group consisting of COOR2a and H,
- R2a is selected from the group consisting of H and C1-C6 alkyl, and
- R3 is a prenyl moiety and the prenyl moiety is 3,7-dimethylocta-2,6-dien-1-yl;
- wherein the cannabinoid derivative is selected from the group consisting of:
- wherein R is H or CH3;
- or
- wherein the cannabinoid derivative is
- and R1 is C1-C20 haloalkyl or C2-C20 alkenyl;
- and
- a pharmaceutically acceptable excipient.
9 more elements
Dependencies are inferred from the claim text.