Filter device for dialysis applications

A device for use in peritoneal dialysis consisting of:

• (i) a filter device;
• and
• (ii) a post-filtration system,
• wherein the filter device comprises:
• a housing comprising a first port and a second port;
• and
• a hollow fibre membrane formed from hollow hydrophilic fibres within the housing, where each of the fibres have an inner surface and an outer surface, wherein
• the hollow hydrophilic fibres comprise a porous wall matrix;
• and
• the inner surface of the hollow hydrophilic fibres are aligned co-axially with respect to the alignment of the first port and the outer surface of the hollow fibres is aligned perpendicularly with respect to the alignment of the second port, such that, when used:
• a dialysate from a subject enters the filter device through the first port is filtered through the porous wall matrix, and the filtered dialysate exits via the second port in an outflow direction;
• and
• a regenerated dialysate from a sorbent system enters the filter device through the second port, passes through the porous wall matrix, and exits via the first port in an inflow direction,
• and wherein the post-filtration system consists of:
• (a) a switch;
• (b) a post-filtration sorbent compartment;
• and
• (c) fluid connections connecting the post-filtration sorbent compartment, the switch and the first port of the housing,
• wherein the post-filtration system and filter device together form:
• a first fluid pathway consisting of the first port of the housing, the switch and a fluid connection therebetween;
• and
• a second fluid pathway consisting of the first port of the housing, the switch, the post-filtration sorbent compartment, and a fluid connection therebetween;
• where the switch is suitable for selecting between the first and second fluid pathways,
• where the first and second fluid pathways are both fluidly connected to the first port of the housing via the switch,
• where the post-filtration sorbent compartment comprises a post-filtration sorbent that is suitable for removing one or more of water-soluble uremic toxins, protein-bound uremic toxins, low-molecular weight proteins, endotoxins, exotoxins, inflammatory mediators and microorganisms.