Optimizing the operation of a chromatography system

A chromatography system for purifying a feed comprising at least one target product having a plurality of purifying units, each purifying unit having an inlet and an outlet, and a valve assembly comprising a single rotary valve, an outlet port, and an inlet port, wherein the inlet and the outlet of each purifying unit being connected to a respective port of the valve assembly, said chromatography system further comprises a control unit configured to:

• a) load the plurality of purifying units with feed provided through the inlet port of the valve assembly by sequentially connecting each purifying unit to the inlet port of the valve assembly;
• b) when step a) completed, elute the plurality of purifying units using a solution to elute provided through the inlet port of the valve assembly by sequentially connecting each purifying unit to the inlet port of the valve assembly;
• and
• c) collect the at least one target product from the outlet port of the valve assembly;
• wherein the loading step is performed for each of the plurality of purifying units, then the eluting step is performed for each of the plurality of purifying units, and then the collecting step is performed for each of the plurality of purifying units, such that the purification of the feed is a semi-continuous process;
• wherein each purifying unit of the chromatography system is a membrane adsorber;
• and
• wherein the plurality of purifying units are connected in parallel.