Devices and related methods for light-based modulation of foreign body responses in living tissue

A method of modulating a foreign body response, the method comprising:

• providing a foreign body within a region of subcutaneous tissue of a host, the foreign body comprising a sensor probe having an active sensing region proximate a distal end of the sensor probe;
• providing a light source capable of emitting one or more peak wavelengths of light, the one or more peak wavelengths comprising a first wavelength in a range from 400 nanometers (nm) to 450 nm;
• inserting a light delivery structure through skin of the host such that a distal end of the light delivery structure is separated from the active sensing region by a portion of the region of subcutaneous tissue and the distal end comprises a light-scattering region integral to the light delivery structure, wherein the light-scattering region is positioned at an offset depth above the active sensing region and the light delivery structure is optically coupled with the light source;
• and
• irradiating one or more portions of the region of subcutaneous tissue with the light through the light-scattering region of the light delivery structure to modulate a foreign body response within the region of subcutaneous tissue.