Heat-resistant implantable polymer microneedle and preparation method therefor and application thereof
AssigneeTechnical Institute of Physics and Chemistry of the Chinese Academy of Sciences
InventorsYunhua Gao, Xiaoyu Zhao, Suohui Zhang
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Abstract
Disclosed are a heat-resistant implantable polymer microneedle and a preparation method therefor and an application thereof. The microneedle comprises a needle tip, a needle body, and a base, wherein the needle tip comprises a homogeneous system formed by mixing a biodegradable macromolecular material which has a glass transition temperature of 35-65° C. and is difficultly soluble in water and a macromolecular material having a glass transition temperature higher than that of the biodegradable macromolecular material. The microneedle has good heat resistance and puncture property.
Claims16
A heat-resistant implantable polymer microneedle, comprising a needle tip, a needle body, and a base, wherein
- the needle tip comprises a homogeneous system formed by mixing a biodegradable macromolecular material A which has a glass transition temperature of 35-65° C. and is substantially insoluble in water at 25° C. and a macromolecular material B having a glass transition temperature higher than that of the biodegradable macromolecular material A
- wherein the glass transition temperature of the macromolecular material B is above 130° C., and
- wherein, in the needle tip, a mass ratio of the macromolecular material B to the biodegradable macromolecular material A is 0.1:1-0.6:1.
Dependencies are inferred from the claim text.