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US 12,616,823 B2Granted
Sustained release formulations in delivery devices
AssigneeArgenta Innovation Limited
InventorsDavid Anthony Gill, Desmond Ian John Morrow, Michael Venning
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Abstract
An intra-ruminal device includes a body substantially impervious to rumen fluid, the body including a barrel, at least one outlet, at least one matrix including at least one active ingredient and at least one clay mineral, a compression arrangement and at least one variable geometry device dependent from the body. Use of the intra-ruminal device and a method of treating a ruminant animal by administering the intra-ruminal device to the animal are also disclosed.
Claims20
An intra-ruminal device comprising
- a body substantially impervious to rumen fluid, the body comprising a barrel, at least one outlet, and at least one matrix in the barrel,
- a compression arrangement within the body adapted to bias the at least one matrix in the barrel to the at least one outlet, and
- at least one variable geometry device dependent from the body to assist rumen retention;
- wherein the at least one matrix in the barrel comprises at least one active ingredient, 5% to 50% by weight of a gel former comprising a sucrose fatty acid ester, and 5% to 40% by weight of at least one clay mineral;
- and
- wherein the device is configured to provide a sustained delivery of the one or more active ingredients over a period greater than 150 days.
3 more elements
Dependencies are inferred from the claim text.